Researchers have developed a greener and more sustainable approach to extracting paclitaxel, an important anti-cancer compound naturally found in the Chinese yew (Taxus chinensis).
Paclitaxel is widely recognised for its role in cancer treatment, making efficient extraction methods important for pharmaceutical research and development. Conventional extraction processes, however, often rely on organic solvents that may pose environmental and safety concerns.
To address this, the study explored the use of a natural deep eutectic solvent (NADES) together with ultrasonic-assisted extraction (UAE). NADES provides a more environmentally friendly solvent system, while ultrasonic technology helps improve the release of target compounds from plant materials.
The researchers also applied statistical modelling and process optimisation to determine suitable extraction conditions. This approach helped achieve a higher extraction yield while reducing the environmental impact associated with conventional solvent-based methods.
Beyond the successful extraction of paclitaxel, the resulting extract demonstrated strong antioxidant activity, further highlighting the potential of this green extraction approach.
The findings show that combining NADES with ultrasonic-assisted extraction could provide a more sustainable alternative for recovering valuable plant-based compounds. More broadly, the research demonstrates how green chemistry can contribute to safer and more environmentally responsible processes in pharmaceutical and medicinal development.